A cure for sickle cell disease from our own bodies…
We are very proud to announce major progress in the search for a cure for sickle cell disease (SCD), the first genetic disease to be understood and a major disease that kills an estimated half-million people world-wide each year. As high as one in every four black persons in certain parts of Africa carries the sickle cell gene. In the United States the incidence is 1 in 12 for African Americans, and approximately 78,000 have SCD. Dr. Robert H. Broyles, a medical school professor and researcher in Oklahoma City, has discovered a protein that is grown in our own bodies that will silence the sickle cell gene and activate a normal gene in its place. Unlike current treatments that are only partially effective or treat the damage caused by SCD, this cure is very specific for the cause, easy to deliver, and beneficial to the whole body. We are working to get this treatment through safety trials and into the clinics where it will be available to all who have sickle cell disease. Our vision is a global one: our goal is to get this cure to each of the millions of people world-wide who have SCD and/or Beta-Thalassemia.
What stage in development process are researchers in with this?
good night,
We are an Ong to Brazil that also seeks to research treatment for SC. We would like to receive detailed information about their study and how we can help them.
We are also in the process finalizing with natural products which directly affect the bone marrow, and causes the same change its genetic memory beginning to produce normal red blood cells. Tell us about your work!
Thanks
Wilson
Would like to know how safe and effective this cure is going to be. Is there any side affect? Is it going to be a generic cure? meaning is it meant for all ages? and is there hope for my 5months old baby in terms of cure? May God almighty assist you in achieving an unprecedented result.
Will keep in touch.
If the cure does work there will be alot of happy people. would this cure eliminate the traite or can the trait be eliminated?
Dear Indy,
Our treatment will not eliminate trait, since it does not alter or eliminate any genes. Thus, newborns who inherit two copies of the sickle gene will still be susceptible. But, because these new babies can be treated inexpensively with our newly discovered GRT and be prevented from ever having any of the symptoms of sickle cell, they should be able to lead long, normal, and healthy lives. Please help spread the word. We need many people from all over the world to donate to our non-profit effort to make this a reality.
Many thanks.
Robert H. Broyles, Ph.D.
President, SCCF
Dear Adeola,
By every indication, in all of our hundreds of experiments, this treatment will be safe and universally effective. But, to be sure that the treatment will be safe in people as well as effective, we must do trials in animals. We were just approved on November 11, 2009, to start these animal trials – which we can do as soon as we have enough funds to pay for the housing of the mice. If these animal trials go well, we hope to move quickly to Phase I/II human clinical trials, which will cost much more. This is a non-profit effort; and obviously, we need a lot of people to donate to this effort. Please help spread the word. Donations by credit card can be made by clicking on the gold “Donate” button on the website. And checks may be mailed to The Sickle Cell Cure Foundation, 601 NW 13th Street, OklahomaCity, OK 73103, U.S.A.
Please do keep in touch, and please spread the word. You may email me at robert-broyles@ouhsc.edu.
Thank you very much.
Robert H. Broyles, Ph.D.
President, SCCF
Dear Wilson,
Thank you for your interest. There is a lot of information about our work accessible from our webpage, especially from the sections titled “Our Research” and “Breaking News.” Under these sections you will find very recent posts entitled “Plan to Cure Sickle Cell Disease,” “Peer Review & Validations of SCCF’s Discovery – Our Credentials (including citations to many publications),” and “Our Research – Gene Regulation Therapy.” We welcome your specific questions. And we hope that you will help us get our treatment tested in Brazil. Please keep in touch.
Sincerely,
Robert H. Broyles, Ph.D.
President, SCCF
Dear Karen,
We very recently (Nov. 11, 2009) received approval to start the first animal trials for safety and effectiveness of GRT, our new treatment. Before we can start, we must have enough money to pay to house the mice during these trails. The next stage will be Phase I/II human clinical trials, which will require much more funding. Please help spread the word. We need as many people as possible donating to this no-profit effort, either through the website with a credit card (click on the gold “Donate” button) or by sending a check to The Sickle Cell Cure Foundation, 601 NW 13th Street, Oklahoma City, OK 73103, U.S.A.
Thank you very much.
Sincerely,
Robert H. Broyles, Ph.D.
President, SCCF
I have a 7 year old son with sicklecell disease and I would like to know what a smalltwn (HIAWATHA, Ks.) mother of two can do to help my son and others like him???? please respond. I have prayed for 7 years for a cure to this painful disease for my son and family and at last, its here,please let me andmy family know what we can do to help you help us.
I would also like to add, when you start doing the trials on humans, please keep us informed so I will know what to do to see if my son is a candidate for the trial. Thank you..
Dear Robinette Brown,
I hope that your 7-year-old son with sickle cell is getting good health care. I will definitely keep you informed through this website about our progress in trying to get this treatment into human clinical trials. You and your friends can help by sending your donations, no matter how small or large, as frequently as possible as checks made payable to The Sickle Cell Cure Foundation, Inc., 601 NW 13th Street, Oklahoma City, OK 73103. Or, you may donate by credit card by clicking on the gold “donate” button on the website. This is a good time of year to donate to charities such as the SCCF since all donations are 100% tax-deductible and can help reduce your tax bill for 2009!
Thank you, and all the best for the holiday season!
Robert H. Broyles, Ph.D.
President, SCCF
My son has the Sickle C (not the common SS) – Will he be a candidate for the breakthough treatment in the future?
Dear Linda Ayo, whose son has SC disease (sickle cell combined with hemoglobin C),
Yes, our treatment should work as well for SC as for SS. Thanks very much for your question. We at SCCF send you and your son our very best wishes. Please keep in touch.
Robert H. Broyles, PhD
President, SCCF
I wish you well.I will be coming.
My husband is 24 and has SS. Im really interested in the trials in the future. Upon approval and funding will there be a list that we would need to get him signed up to or is there already a waiting list?
Hi, I am a 25 years old man from haiti (an african descendant country) with the SC disease, can i be a candidat for your treatment in the future? Let me know what i can do to help
Dear Jean David,
Yes, I sincerely hope that you can be a candidate for our treatment in the future. We hope that the future is short – no more than a few years. Yes, you can help by getting as many people as possible to donate through this website. I wish you a good year for 2010.
Sincerely,
Robert H. Broyles, PhD
Presidebt, SCCF
Dear Sabra Denson,
When or funding is obtained and the treatment is certified for distribution, we will notify everyone throgh this website and/or by email. Thus, you and those who register here or submit comments are automatically registered. I wish you and yor husband the best for 2010.
Sincerely,
Robert H. Broyles, PhD
President, SCCF
please get me inform when you started doing the trials for human,please
Dear Anthony,
We will make an announcement on this website.
All the best,
Robert H. Broyles, PhD
President, SCCF
I am a Nigerian but leave in Germany and my two children were yesterday tested positive to SS. My son is two years with the sister three months old. Please can we be notify of any future advance in this your research as it will safe alot of souls of both the carrier and their parents. I almost ended my life yesterday even now im in serious shock. My own case is severe because i lost my only brother because of sickle cell and now my two kids are sickler again. Please help me for I will be most glad if you help and ready to come to U S with my kids.
Dear Fabian Emmaneul and readers,
Through personal emails, I and this family have corresponded. Sickle cell is a terrible thing for a family to deal with when one child is affected, and two is a much harder situation. We at SCCF are working as hard as we can. Progress is slow because funding is low. That is the bottom line that we face daily. Please see our website for the progress in 2009 – we have a new post under Breaking News that is the first thing to come up. All of that progress was made on less than $10,000 US total revenues in 2009. We need to – we must – do much better in funding this work.
My heart goes out to this family and all of those who have sickle cell, including all of those who are trapped by the earthquake in Haiti. The many people with sickle cell in Haiti face a life or death situation. They need water, shelter, and proper emergency care. And there are many world-wide that we do not hear about who daily face death from sickle cell. It is for all of these as well as those who have the means to correspond on this site, that we do this work.
Robert H. Broyles, PhD
President, SCCF
Hello Dr. Broyles,
Thank you for kindly responding to these messages. And thank you for keeping us posted on your progress. I am a Nigerian living in Canada and am SS genotype. I do hope that the needed funds will pour in.
To the parents of children with SS or SC and the Nigerian man in Germany who found out that his children are SS, I pray that you do not lose hope. I will be celebrating my 40th birthday this year, by the grace of God. Living with this disease has been challenging for me and my family, but we have persevered. I was able to complete a university degree, work for the government, and volunteer at my church and community with this condition. While we wait for this cure, I hope you will be encouraged.
I have a 14month old son who is ss thou has neva had any crises.I hope this works out n pls kip me posted on any update.I’ll send my donation as soon as possible n I hope the trials will be ova and the drugs out as soon as possible
Hello,
I am from Jamaica. Will this cure be for younger patients I am now 38 years old and I am wondering if I would be two old to get this cure
Dear Arlene,
The cure will be for all ages and available to all as soon as it clears clinical trials and is approved. You will not be too old!
Please do not lose hope! And check this website for news and for comments from others who have sickle cell. You are welcome to use this site to communicate with one another.
All the best,
Robert H. Broyles, PhD
President, SCCF
Dear Sadiya,
I am happy to hear that your 14-month old baby has had no crises, and I hope that his SCD has a mild course. We will post all updates on this website regularly, and we will also send newsletters to those who register for them. See the home page, right-hand side, for a sign-up form for newsletters and announcements.
Thanks for being willing to donate. We will look for your donation in the mail or through PayPal. (See the Comment to Precious under “Plan to Cure Sickle Cell…” under Breaking News, for details on how to donate.)
All the best,
Robert H. Broyles, PhD
President, SCCF
Dear Angela Njoku,
Thanks you very much your comment and your encouragement to others with SCD, not to lose hope.
The funds are not exactly rolling in, although a few made generous donations in December, at the end of the U.S. tax year. A lot of small donations each month would be just as valuable as a few larger ones. So, everyone, please send a donation each month, even if it is just a small amount. Every donation is a help and keeps our progress going forward.
Thank you very much!
Sincerely,
Robert H. Broyles, PhD
President
SCCF
My friend is turning 21 this year (2010) and she has sickle care. I wish thise disease she didnt have o live with and ill do anythin to have her cured please do you best and lets all pray and hope this cure is the one. No one deserves hurt or pain. How long will it be before this cure is available would u estimate?
My friend has sickle cell and she is 20. She will be 21 in 2010. Will she have this cure? If so, then how long is it gonna be before its universal and affordable? Whats the estimate time?
So when will this cure be avalable if successful?
Dear Matthew Davis (Matt),
Thank you for your three comments and questions. The time estimate for the cure to be universally available and affordable, if all goes according to the plans, is three-to-five years. The governments of some countries may make it more difficult than others, and there are other variables such as interactions with other NGOs that make a more exact estimate difficult. But it should be soon enough for your 20-year-old friend to benefit. Please convey my best wishes to her.
Sincerely,
Robert H. Broyles, PhD
President, SCCF
Iam a mother of six and out of six five had sicklcells can u imagine the pain i go through and the blame i put on myself.Two of my children have died so far. i hve three remaining but my son suffers most he goes thru too much pain. as a mother i hve kep on promising that i will take him to countries wher we can get proper management and treatmant
ai pray all the time for a miracle in terms of a cure and if ure doing something about it may God bless u ann also guide because we parents the pain we go through doesnt have medicine.please wen time comes put my chilren on trial
Dear Alice,
Thank you very much for your message. I am so sorry to hear of the deaths of two of your children. It is for people like you, families like you that we are doing this work. We are trying to move this treatment forward as fast as our funding allows. Meanwhile, I wish the very best for you and your three remaining children. Please let me know, from time to time, how all of you are. And, if you would, please let me know where you live and what health care is available. Please do not give up hope,
Sincerely,
Robert H. Broyles, Ph.D.
President
SCCF
I come from U ganda ,we have sicklecell clinicb ANut its only one in the whole coutry and when you see it believe me you will cry.The gov doesnt care so much about sicklecells as its with HIV AIDS. WEsuffee sometimes we dont have doctors nor medicine i will ask agin when time comes for the trial please include my children Yes i live in hope.And thank you.
Alice
Hello,
I have an eight year old son who is a sickler.He’s such an adorable boy and it breaks my heart to see him cry each time he has a crisis.I pray for the success of this cure as soon as possible so that smiling faces can return to families with this problem.I can’t wait to donate to this cause bcs it’s worth doing.
May God Almighty strengten you in your effort .
Yours sincerely,
CYNTHIA.
Thank you, Cynthia. I wish you and your adorable boy the very best possible.
And thank you for your promise to donate.
Robert H. broyles, Ph.D.
President, SCCF
I have to Thank Njoku my sister for her word of encouragement. I am so happy to hear that you are upto 40years now. I Give God Praise for your life and pray that this cure will come out soon for all of us. My children were having crises all along. my son had blood transfusion and i even lost my job bc i lacked concentration and i spent much time with him. I was in pathetic state all this while but i give God praise that atleast for now their are hope for cure of sickle cell anemia.
Dear Robert please i will make my own donation soon bc if i look back to people in Africa that do not have good medicare i feel we all that even have priviledge to this site have to help and Donate nomather how little. Once more I pray that God will guide and protect you people and all the brothers and sisters that are sickler so that we all will benefit from this.
hi prof, I sent you an email offering to use the status of my company being an entertainment company to raise funds for your project believing God that your cure will work and sweet fiance will not have to suffer this ill but you have not replied me. I want to guarantee you that I am very well connected here and can raise for this cause up to $1m if all goes well, please respond so we can set the ball rolling, my girlfriend’s hopes are alerady high.
Thanks
Dear Broyleser
I got nothing much to say but Thanking you for your greate work.
MAY GOD TRULY BLESS YOU AND YOUR ORGANISTON…..
Dear Fabian,
I thank you and your sister Njoku for your words of encouragement to others with SCD. I sincerely hope that all of you can stay as well as possible. And I thank you for your desire to donate to our effort. The simplest way to do this is to send a personal check made out to The Sickle Cell Cure Foundation to: SCCF, 601 NW 13thStreet, Oklahoma City, OK 73103. Donations may also be made by credit card through PayPal by clicking the gold “donate” button on the SCCF website; but, PayPal takes a percentage (a service fee) out of every donation. Many thanks!
Sincerely,
Robert H. Broyles, Ph.D.
President
SCCF
Dear Boye,
Thank you for your Comment on this site – because I do not think your email got through. SCCF is very eager to work with you to help raise funds for getting this cure through clinical trials. Please try your email again, sending it simultaneously to these two email addresses: robert-broyles@ouhsc.edu; and robert.broyles@sicklecellcurefoundation.org. I hope to hear from you again soon. Many thanks.
Sincerely,
Robert H. Broyles, Ph.D.
President
SCCF
Dear A.J. Solomon,
Thank you very, very much! God bless you…
RHB
Dear, Mr. Broyles
My son Nasir Morrow is 7 years old and has sickle cell disease. While I was pregnant with my son, my mother passed away from SSD at the age of 51. Many doctors have told her that she was one of the lucky ones to have lived that long. As a mother without my mother I am very sad within my soul to see the pain and hurt that my son has to go through living life. I pray everyday for a miracle, and for my son to be of many of the blessed to receive a blessing with a cure and end to the pain. This is the hardest thing ever in my life that I have to deal with and I’m sure as a child that he has to go through. Its terrible to see so much of his childhood stripped away by pain. He spent his sixth birthday in the hospital, and the crisis are continously overwhelming. I know there are thousands of wishes and hopes and prayers from all of us worldwide who are dealing with this disease, and with God’s will, your hard work, our faith, I do believe, and have hope. Unfortunately my mother didn’t benefit, and by the grace of God, I am praying that my son does. I am also praying for a miracle with the donations and fundings for this cause. Please keep my son in mind when the trials begin and thank your for your time.
Sincerely,
Parthenia Morrow
Dear Parthenia Morrow,
I am so very sorry to hear about your mother’s death. I know what a blow that can be. I am also very, very sorry to hear of your seven-year-old son’s pain from SCD. Please check our website in May for our progress. As we work, your son will be in my mind every day.
All the best to you and your son,
Robert H. Broyles, PhD
President, SCCF