Devastation Shall Be Overcome

The Sickle Cell Cure Foundation, Inc. (SCCF) is a non-profit 501(c)(3) research foundation incorporated in 2006. SCCF chose the PHF Research Park as its world headquarters to conduct translational research using patented treatments aimed at curing two of mankind’s most devastating diseases: malaria and its allied blood disorder, sickle cell disease (SCD). The Bill & Melinda Gates Foundation recently awarded a Grand Challenge Exploration grant to SCCF to conduct its animal safety and efficacy trials. SCCF aims to raise additional funds for human clinical trials required for FDA approval. The therapeutics offered by SCCF are inexpensive, non-invasive, and easy to deliver; and SCCF’s mission fits the Gates’ central philanthropic principle that “all lives have equal value”.

SCD is a disease that co-evolved with malaria among peoples living in equatorial regions where mosquitoes are endemic and serve as vectors for the malaria parasite. In the US, over 70,000 individuals are afflicted with SCD. Globally, an estimated 880,000 die from malaria and 340,000 from SCD annually, with the great majoriy of these deaths being children under the age of five years. SCD afflicts many in western and central African countries, as well as people of Portuguese, Spanish, French Corsican, Sardinian, Sicilian, Italian, Greek, Turkish, Cypriot, Israeli, Arab, and Indian decent. While one copy of the sickle gene confers resistance to the malaria parasite, carrying two copies can result in death. Large public health measures have limited the spread of malaria in developed countries. In contrast, SCD has been neglected. The wide spread occurrence of SCD and recent resurgence of malaria motivated the World Health Organization in May 2006 to list SCD as a neglected disease warranting intensified research. SCCF is mounting a global effort to address this global health problem.

Gene Regulation Therapy (GRT) is the overall research approach employed by SCCF. GRT does not destroy genes, alter them, nor implant them in the patient. Rather, SCCF has discovered how to manipulate “toggle switches” that reactivate the body’s own fetal hemoglobin production. Medical literature has amply documented that the presence of fetal hemoglobin in adult red blood cells at concentrations of 30% or more confers a natural resistance to SCD…and also to malaria. Requiring no refrigeration, the GRT for SCD is natural, non-invasive, and reversible. To maintain its benefits, the patient only requires periodic “recharge” doses to keep the toggle switch “on.” Similar GRT-responsive, “onoff” genetic relationships are the subject of translational research and development. GRT promises effective clinical treatments for many debilitating disorders including diabetes, Parkinson’s, Huntington’s, liver diseases, and certain cancers. SCCF’s business plan for global distribution of Gene Regulation Therapy for SCD estimates a 95% drop in the cost of standard Western treatments. Whereas current treatments only address the symptoms of SCD, SCCF’s approach corrects the primary cause. For the world’s poor majority, SCCF’s business model uses cross-subsidy pricing to deliver the cure to Africa pharmaceutical outlets for as little as US $12.00 per person per year.


  1. Welldone!!! This is 2011, when will this drug be made available?

  2. I think this is great!! Thank you for the years researching and coming up with this. This epidemic is so painful, and It’s really sad that many sickle cell patients are not knowledgeable about what medicines to take on a regular basis to live healthy, what’s even more sad about this disease is that sc patients go to the hospital…get pain medicne…maybe a blood transfsion and get sent home with no solution.

    I’m so happy that this will all change slowley but surely!!! I am a sickle cell patient but I am healthy, yet my eyes ar always jaundice and it’s still horrible when I do have crisis, thank you for this cure I will definitely donate

  3. My name is Steven and I am writing on behalf of my late brother in law and best friend Isaac Flores. Isaac was reffered to as ‘Superman’ by his local doctors due to his unique form of the disease and his ability to overcome crisis after crisis during his 43 years of life. Isaac passed away on 6/3/11 of a stroke related to SCD. He left behind a loving wife two children, three step children, eleven brothers and sisters (one of whom also suffers from SCD) a loving mother and a countless number of friends. Most of all he left behind a legacy of love and compassion unequaled by most. He was a devoted Paramedic and instructor, hunter, fisherman and all arourd lover of the outdoors. We love what the SCCF is doing and we hope that through their efforts we can end the suffering caused by this horrible illness. Keep up the good work. His wife has asked that instead of flowers and cards given in sympathy for the loss of Isaac, donations to the SCCF and blood donations be given in his name. It is what he wld have wanted. Thank you guys for all that you are doing to try and prevent the suffering of all affected by SCD.

    • Dear Steven.
      I am so sorry to hear about your brother-in-law’s passing. He, Isaac Flores, sounds like a terrific person. Thank you for writing about him. And thank you for your encouragement to us in our efforts and for telling all of those who knew and loved Isaac.
      All of us send our best to you,
      Robert H. Broyles, PhD
      SCCF President/Lead Scientist

  4. wonderful, calms my nerves, relief my pain and fear, but am extremely anxious. Men what are we waiting for? Please come and pick my patients for trial. This disease has kill my close friends/patients.

    When are we expecting this medicine on the shelves? How do we donate from Nigeria?

  5. Sharmaine says

    God Bless You 🙂
    & Thank You 🙂

  6. Thank you

  7. I have a daughter with Sickle Cell. When will the treatment be available?

  8. Thank u so much. U’re like a messiah to us that are suffering from the disease. Please what stage are u now? And when are we expecting d drug in Nigeria bcos Nigeria has the highest sufferers of the disease in the world.
    Once again, thank u & God bless u..

  9. I am very happy 2 hear that there’s a step in d right direction towards a permanent end 2 dis killing ailment. pls try 2 get 2 Nigeria soon as some of us suffer neglect & stigma even from of our family members. May God grant crown your effort.

  10. Hello doctor,i am very glad about your efforts for us please my question will the red blood cell be strong and will children with scd grow like there friend if they are taking this medicine.thank you and may God bless you.

  11. God alone will reward you greatly. Pls and pls how do i get the said drugs? My daughter is in agressive pain rightnow. Pls help me!! Also send me an email address i can use to reach one of your doctors regards

  12. Hello Sir,

    I have seen this like several months back and I was expecting that the drugs will be out in 2012.

    Can I suggest that you increase your targeted retail costs, this may bring it out faster (since there is a ready market).

    The reason is that there are several sickle cell foundation in many countries who may eventually subsidize the cost of purchase and may not be aware of all your efforts right now.

    The costs of waiting is several times more than $12 per year for the sufferers of SCD, a lot of hospital bills, some have died.

    A lot of us are looking forward to the eventual availability of one the best product of all times.

    Please, will it be released this year, is it already available in the US.


    • broylesr says

      Thank you for the suggestions. We cannot predict yet when our treatment will be available. But we are moving as fast as we can.

    • I wouldn’t wish this diesase on my worst enemy. Its a total nighmare. When I’m in pain I pray and pray and pray for God to give me a little relief ..yet he doesn’t. Makes me wonder why ? Pain won’t leave you alone sometimes. I’m enduring a sickle cell ulcer. A new level of OUCH!

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